Pathogenesis, diagnosis, and therapy of feline idiopathic megacolon

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Scientific advances in the past decade have brought new understandings to the pathogenesis and therapy of feline colonic motility disorders. Epizootiologic studies have shown, for example, that 96% of the documented cases of obstipation are accounted for by idiopathic megacolon (62%), pelvic canal stenosis (23%), nerve injury (6%), or Manx sacral spinal cord deformity (5%). Recent physiologic studies suggest that most of the idiopathic cases result from colonic smooth muscle dysfunction. The latter studies have also provided evidence that colonic prokinetic agents are useful adjunctive therapy in the treatment of constipation. Many cats are now successfully treated with multicomponent therapy (i.e., dietary fiber supplementation, emollient or hyperosmotic laxatives, and colonic prokinetic agents). Those cats who fail to respond to conservative medical management will generally manifest marked clinical improvement with subtotal colectomy.

Original languageEnglish (US)
Pages (from-to)589-603
Number of pages15
JournalVeterinary Clinics of North America - Small Animal Practice
Volume29
Issue number2
StatePublished - Jan 1 1999

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megacolon
Megacolon
Felidae
pathogenesis
cats
therapeutics
laxatives
Spinal Cord
constipation
Cats
Emollients
spinal cord
smooth muscle
Laxatives
Colectomy
nerve tissue
Dietary Fiber
dietary fiber
Constipation
Therapeutics

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Pathogenesis, diagnosis, and therapy of feline idiopathic megacolon. / Washabau, R. J.; Holt, D.

In: Veterinary Clinics of North America - Small Animal Practice, Vol. 29, No. 2, 01.01.1999, p. 589-603.

Research output: Contribution to journalReview article

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