Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19

Natalie M. Kirk, Yuying Liang, Hinh Ly

Research output: Contribution to journalReview articlepeer-review

Abstract

Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.

Original languageEnglish (US)
Article number2316438
JournalVirulence
Volume15
Issue number1
DOIs
StatePublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Respiratory pathogens
  • animal models
  • coronaviruses
  • pathogenesis
  • pathology

PubMed: MeSH publication types

  • Journal Article
  • Review

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