Pathogenesis and pathology of graft-vs.-host disease

John E. Wagner, Georgia B. Vogelsang, William E. Beschorner

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Over the past decade, there has been a significant increase in the number of patients with a variety of malignant and nonmalignant disorders referred for bone marrow transplantation. Despite numerous advances in the care of such patients after allogeneic bone marrow transplantation, acute and chronic graft-vs.-host disease continues to be a prinicipal cause of morbidity and mortality. In this article, we will present an overview of the pathogenesis, clinical presentation, and pathological manifestations of these two major complications.

Original languageEnglish (US)
Pages (from-to)196-212
Number of pages17
JournalAmerican Journal of Pediatric Hematology/Oncology
Issue number2
StatePublished - 1989


  • Bone marrow transplantation
  • Graft-vs.-host disease
  • Pathogenesis
  • Pathology


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