Pathogenesis and outcome of extrahepatic biliary obstruction in cats

P. D. Mayhew, D. E. Holt, R. C. Mclear, R. J. Washabau

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Extrahepatic biliary obstruction (EHBO) was confirmed at surgery or necropsy in 22 cats. Biliary or pancreatic adenocarcinoma was diagnosed by histopathology in six cats and one cat had an undiagnosed mass in the common bile duct. The remaining 15 cats had at least one of a complex of inflammatory diseases including pancreatitis, cholangiohepatitis, cholelithiasis and cholecystitis. The most common clinical signs were jaundice, anorexia, lethargy, weight loss and vomiting. Hyperbilirubinaemia was present in all cases. Distension of the common bile duct and gall bladder was the most commonly observed finding on abdominal ultrasound. Nineteen cats underwent exploratory laparotomy for biliary decompression and diversion. Mortality in cats with underlying neoplasia was 100 per cent and, in those with non-neoplastic lesions, was 40 per cent. Long-term complications, in those that survived, included recurrence of cholangiohepatitis, chronic weight loss and recurrence of obstruction. Based on these findings, the prognosis for EHBO in cats must be considered guarded.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalJournal of Small Animal Practice
Volume43
Issue number6
DOIs
StatePublished - Jan 1 2002

Fingerprint

cholestasis
Cats
pathogenesis
cats
bile ducts
Common Bile Duct
Weight Loss
weight loss
cholecystitis
hyperbilirubinemia
cholelithiasis
Recurrence
Lethargy
jaundice
Cholecystitis
Hyperbilirubinemia
Cholelithiasis
pancreatitis
gall bladder
intestinal obstruction

Cite this

Pathogenesis and outcome of extrahepatic biliary obstruction in cats. / Mayhew, P. D.; Holt, D. E.; Mclear, R. C.; Washabau, R. J.

In: Journal of Small Animal Practice, Vol. 43, No. 6, 01.01.2002, p. 247-253.

Research output: Contribution to journalArticle

Mayhew, P. D. ; Holt, D. E. ; Mclear, R. C. ; Washabau, R. J. / Pathogenesis and outcome of extrahepatic biliary obstruction in cats. In: Journal of Small Animal Practice. 2002 ; Vol. 43, No. 6. pp. 247-253.
@article{7ae7c042a4504872b1a93802757949e3,
title = "Pathogenesis and outcome of extrahepatic biliary obstruction in cats",
abstract = "Extrahepatic biliary obstruction (EHBO) was confirmed at surgery or necropsy in 22 cats. Biliary or pancreatic adenocarcinoma was diagnosed by histopathology in six cats and one cat had an undiagnosed mass in the common bile duct. The remaining 15 cats had at least one of a complex of inflammatory diseases including pancreatitis, cholangiohepatitis, cholelithiasis and cholecystitis. The most common clinical signs were jaundice, anorexia, lethargy, weight loss and vomiting. Hyperbilirubinaemia was present in all cases. Distension of the common bile duct and gall bladder was the most commonly observed finding on abdominal ultrasound. Nineteen cats underwent exploratory laparotomy for biliary decompression and diversion. Mortality in cats with underlying neoplasia was 100 per cent and, in those with non-neoplastic lesions, was 40 per cent. Long-term complications, in those that survived, included recurrence of cholangiohepatitis, chronic weight loss and recurrence of obstruction. Based on these findings, the prognosis for EHBO in cats must be considered guarded.",
author = "Mayhew, {P. D.} and Holt, {D. E.} and Mclear, {R. C.} and Washabau, {R. J.}",
year = "2002",
month = "1",
day = "1",
doi = "10.1111/j.1748-5827.2002.tb00067.x",
language = "English (US)",
volume = "43",
pages = "247--253",
journal = "Journal of Small Animal Practice",
issn = "0022-4510",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Pathogenesis and outcome of extrahepatic biliary obstruction in cats

AU - Mayhew, P. D.

AU - Holt, D. E.

AU - Mclear, R. C.

AU - Washabau, R. J.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Extrahepatic biliary obstruction (EHBO) was confirmed at surgery or necropsy in 22 cats. Biliary or pancreatic adenocarcinoma was diagnosed by histopathology in six cats and one cat had an undiagnosed mass in the common bile duct. The remaining 15 cats had at least one of a complex of inflammatory diseases including pancreatitis, cholangiohepatitis, cholelithiasis and cholecystitis. The most common clinical signs were jaundice, anorexia, lethargy, weight loss and vomiting. Hyperbilirubinaemia was present in all cases. Distension of the common bile duct and gall bladder was the most commonly observed finding on abdominal ultrasound. Nineteen cats underwent exploratory laparotomy for biliary decompression and diversion. Mortality in cats with underlying neoplasia was 100 per cent and, in those with non-neoplastic lesions, was 40 per cent. Long-term complications, in those that survived, included recurrence of cholangiohepatitis, chronic weight loss and recurrence of obstruction. Based on these findings, the prognosis for EHBO in cats must be considered guarded.

AB - Extrahepatic biliary obstruction (EHBO) was confirmed at surgery or necropsy in 22 cats. Biliary or pancreatic adenocarcinoma was diagnosed by histopathology in six cats and one cat had an undiagnosed mass in the common bile duct. The remaining 15 cats had at least one of a complex of inflammatory diseases including pancreatitis, cholangiohepatitis, cholelithiasis and cholecystitis. The most common clinical signs were jaundice, anorexia, lethargy, weight loss and vomiting. Hyperbilirubinaemia was present in all cases. Distension of the common bile duct and gall bladder was the most commonly observed finding on abdominal ultrasound. Nineteen cats underwent exploratory laparotomy for biliary decompression and diversion. Mortality in cats with underlying neoplasia was 100 per cent and, in those with non-neoplastic lesions, was 40 per cent. Long-term complications, in those that survived, included recurrence of cholangiohepatitis, chronic weight loss and recurrence of obstruction. Based on these findings, the prognosis for EHBO in cats must be considered guarded.

UR - http://www.scopus.com/inward/record.url?scp=0036615060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036615060&partnerID=8YFLogxK

U2 - 10.1111/j.1748-5827.2002.tb00067.x

DO - 10.1111/j.1748-5827.2002.tb00067.x

M3 - Article

C2 - 12074289

AN - SCOPUS:0036615060

VL - 43

SP - 247

EP - 253

JO - Journal of Small Animal Practice

JF - Journal of Small Animal Practice

SN - 0022-4510

IS - 6

ER -