Pathogen reduced plasma products: a clinical practice scientific review from the AABB

on behalf of the AABB Clinical Transfusion Medicine Committee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


BACKGROUND: A small body of literature assessing the efficacy and safety of pathogen reduced (PR) plasma has been published. STUDY DESIGN AND METHODS: An AABB committee systematically reviewed the literature and graded the clinical trial evidence with the assistance of a GRADE expert. RESULTS: Most studies identified were low quality and had a small sample size; in addition, efficacy and safety were monitored in many different ways making it difficult to quantify therapeutic benefit and risk. The data analyzed in this systematic review showed that pathogen inactivation did not adversely affect the efficacy of S/D or amotosalen plasma transfusions in any patient population studied. In addition, there were no significant safety issues for these patient populations, other than the specific contraindications noted in their respective package inserts. CONCLUSION: Larger, well-designed trials are needed to further evaluate the efficacy and safety of all of the PR plasma products.

Original languageEnglish (US)
Pages (from-to)2974-2988
Number of pages15
Issue number9
StatePublished - Sep 1 2019

Bibliographical note

Publisher Copyright:
© 2019 AABB


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