Patent ductus arteriosus occlusion in small dogs utilizing a low profile Amplatz® canine duct occluder prototype

Christopher D Stauthammer, Janet Olson, Damon Leeder, Kristin Hohnadel, Melissa Hanson, Anthony H. Tobias

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives: To develop procedural methodology and assess the safety, utility and effectiveness of a low profile Amplatz® canine duct occluder (ACDO) prototype in dogs deemed too small to undergo ductal occlusion with the commercially-available ACDO device. Animals: Twenty-one dogs with left-to-right shunting patent ductus arteriosus (PDA). Dogs were ≥1.5 kg but considered too small to accommodate a 6 Fr catheter or 4 Fr sheath within the femoral artery. Methods: Prospective canine study using a low profile ACDO prototype delivered through a 4 Fr catheter via a femoral arterial approach. Procedural methods, fluoroscopy time, perioperative complications, and residual ductal flow were evaluated, and angiographic ductal morphology and dimensions were tabulated. Results: All 21 dogs underwent successful ductal occlusion using the prototype device, 4 Fr catheter, and right femoral artery approach. No perioperative complications or device embolization occurred. The median minimal ductal diameter was 1.9 mm (range, 0.4–3.4), and the median device size deployed was 4 mm (range, 3–6). Complete ductal occlusion was noted in 17 dogs (81%) on post-deployment angiography. Twenty dogs (95%) had no residual flow on echocardiography performed the following day. In the 17 dogs (81%) that returned for a long-term (≥3months) follow-up evaluation, all had complete ductal occlusion based on echocardiography. Conclusions: The low profile ACDO prototype is a safe and effective method of PDA occlusion in the small dog. The deployment procedure appears of similar technical difficulty to the commercially available ACDO.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalJournal of Veterinary Cardiology
Issue number3
StatePublished - Sep 2015

Bibliographical note

Funding Information:
The study was funded by St. Jude Medical.

Publisher Copyright:
© 2015 Elsevier B.V.


  • Angiography
  • Cardiac catheterization
  • Congenital
  • Intervention


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