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Particle-induced osteolysis is mediated by TIRAP/mal in vitro and in vivo
Christopher P. Bechtel
, Jeremy J. Gebhart
, Joscelyn M. Tatro
, Endre Kiss-Toth
, J. Mark Wilkinson
, Edward M. Greenfield
Orthopaedic Surgery
Research output
:
Contribution to journal
›
Article
›
peer-review
21
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Scopus citations
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Keyphrases
Adapter Protein
100%
Particle-induced Osteolysis
100%
TIRAP
100%
Myeloid Differentiation Factor 88 (MyD88)
87%
Interleukin-1 Receptor
87%
Adapter
87%
Toll-like
62%
Pathogen-associated Molecular Patterns
50%
Lipopolysaccharide
37%
Bacterial Debris
37%
Titanium Particles
37%
Bacterial Pathogens
25%
Receptor 2
25%
Aseptic Loosening
25%
Osteolysis
25%
Wear Particles
25%
Endotoxin-free
25%
Free Particle
25%
MAL2
25%
Polymorphism
12%
Macrophages
12%
Interleukin-6
12%
Inflammatory Response
12%
Inflammatory Pathways
12%
Interleukin-1β
12%
Tumor Necrosis Factor-α
12%
Cytokine mRNA
12%
Biologic Response
12%
Calvaria
12%
Cytokine Secretion
12%
Alarmins
12%
Remaining Activity
12%
Inflammatory Osteolysis
12%
Medicine and Dentistry
In Vitro
100%
Myeloid Differentiation Factor 88
100%
Interleukin 1 Receptor
100%
Osteolysis
100%
Pathogen Associated Molecular Pattern
57%
Lipopolysaccharide
42%
Toll Like Receptor 2
28%
Secretion (Process)
28%
Cytokine
28%
Endotoxin
28%
Toll Like Receptor 4
28%
Prosthesis Loosening
28%
Serositis
14%
Toll Like Receptor
14%
Macrophage
14%
Tumor Necrosis Factor
14%
Calvaria
14%
Alarmin
14%
Interleukin 6
14%
Messenger RNA
14%
Immunology and Microbiology
Osteolysis
100%
MYD88
100%
Interleukin-1 Receptor
100%
In Vitro
100%
Pathogen-Associated Molecular Pattern
57%
TLR4
28%
TLR2
28%
Secretion (Process)
28%
Cytokine
28%
Wild Type
28%
Macrophage
14%
Inflammation Response
14%
Interleukin 6
14%
Tumor Necrosis Factor Alpha
14%
Calvaria
14%
Toll-Like Receptor
14%
Pharmacology, Toxicology and Pharmaceutical Science
Myeloid Differentiation Factor 88
100%
Interleukin 1 Receptor
100%
Pathogen Associated Molecular Pattern
57%
Lipopolysaccharide
42%
Cytokine
28%
Endotoxin
28%
Toll Like Receptor 2
28%
Toll Like Receptor 4
28%
Prosthesis Loosening
28%
Tumor Necrosis Factor
14%
Toll Like Receptor
14%
Alarmin
14%
Inflammation
14%
Interleukin 6
14%
Messenger RNA
14%