Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis

Keyphrases

• Spinocerebellar Ataxia 100%
• Ataxin-1 100%
• Partial Loss 100%
• Transcriptional Dysregulation 100%
• Loss Function 30%
• Overexpression 20%
• Neurodegenerative Diseases 20%
• Disease Model 10%
• Cerebellum 10%
• Function Model 10%
• Microarray Profiling 10%
• Molecular Changes 10%
• Functional Mechanism 10%
• Genetic Data 10%
• Gene Expression Changes 10%
• Molecular Data 10%
• Transcriptional Changes 10%
• Molecular Defects 10%
• Polyglutamine Tract 10%
• Gene Expression Microarray 10%
• Behavioral Defects 10%
• Shared Genetics 10%
• CAG Repeat 10%
• Evolutionarily Conserved 10%
• Gain-of-function Mechanism 10%

Biochemistry, Genetics and Molecular Biology

• Ataxin 1 100%
• Mouse 75%
• Genetics 25%
• RNA 25%
• DNA Microarray 25%
• Wild Type 25%
• Polyglutamine Tract 25%
• Gene Expression 25%
• CAG Repeat 25%
• Paralogy 25%

Neuroscience

• Ataxin 1 100%
• Spinocerebellar Ataxia 100%
• Neurodegenerative Disorder 20%
• Cerebellum 10%
• Gene Expression 10%
• CAG Repeat 10%
• Polyglutamine 10%
• DNA Microarray 10%