Partial feed restriction decreases growth hormone receptor 1A mRNA expression in postpartum dairy cows

R. P. Radcliff, B. L. McCormack, D. H. Keisler, B. A. Crooker, M. C. Lucy

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Uncoupling of the growth hormone (GH) axis in early postpartum dairy cows is correlated with a decrease in liver GH receptor (GHR) 1A mRNA and a decrease in liver GH receptor protein. Postpartum recoupling of the GH axis is also correlated with GHR 1A mRNA and GHR protein. We hypothesized that dry matter intake (DMI) partially controls the increase in GHR 1A mRNA postpartum. Prepartum Holstein dairy cows (n = 11) were offered feed ad libitum. After calving, 6 cows were fed 70% of their expected DMI (feed restriction) for 14 d and 5 cows were fed ad libitum (control). Both groups were fed ad libitum after d 14. Liver was biopsied prepartum and on d 1, 7, 14, and 21 postpartum; blood was sampled throughout the experimental period. Rate of increase in postpartum milk production was less for feed-restricted cows. The GHR 1A mRNA decreased from prepartum to d 1 postpartum and subsequently increased. Rate of postpartum increase in GHR 1A mRNA was less in feed-restricted cows. Diminished GHR 1A persisted for at least 7 d after feed-restricted cows returned to ad libitum feeding. Liver insulin-like growth factor-I mRNA concentrations decreased from prepartum to d 1 as well, but were similar for feed restricted and control thereafter. We concluded that DMI partially controls GHR 1A mRNA expression in early postpartum dairy cows and that the decrease in GHR 1A in response to feed restriction persisted for at least 1 wk after ad libitum feeding was restored.

Original languageEnglish (US)
Pages (from-to)611-619
Number of pages9
JournalJournal of Dairy Science
Volume89
Issue number2
DOIs
StatePublished - Feb 2006

Bibliographical note

Funding Information:
This research was supported by the National Research Initiative Competitive Grants Program (USDA CSREES 00-35206-9536 awarded to M. C. Lucy) and by the Missouri and Minnesota Agricultural Experimental Stations.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Growth hormone receptor
  • Liver
  • Nutrition
  • Postpartum

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