Parkinson's disease diffusion MRI is not affected by acute antiparkinsonian medication

Jae Woo Chung; Roxana G. Burciu; Edward Ofori; Priyank Shukla; Michael S. Okun; Christopher W. Hess; David E. Vaillancourt

doi:10.1016/j.nicl.2017.02.012

Parkinson's disease diffusion MRI is not affected by acute antiparkinsonian medication

Jae Woo Chung, Roxana G. Burciu, Edward Ofori, Priyank Shukla, Michael S. Okun, Christopher W. Hess, David E. Vaillancourt

Neurology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objective A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. Methods Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45min after their usual dose of antiparkinsonian medication. OFF-medication, patients were tested after not taking antiparkinsonian medication for >12h. OFF and ON-medication was counter-balanced across subjects. For dMRI, we computed free-water and free-water corrected fractional anisotropy (FAt) within the following regions: caudate, putamen, substantia nigra, and subthalamic nucleus. Results ON-medication significantly reduced parkinsonian motor symptoms compared with OFF-medication (p

Original language	English (US)
Pages (from-to)	417-421
Number of pages	5
Journal	NeuroImage: Clinical
Volume	14
DOIs	https://doi.org/10.1016/j.nicl.2017.02.012
State	Published - 2017

Keywords

dMRI
Parkinson's disease
Antiparkinsonian medication
Free-water
Free-water corrected fractional anisotropy

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10.1016/j.nicl.2017.02.012

http://www.sciencedirect.com/science/article/pii/S2213158217300463

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title = "Parkinson's disease diffusion MRI is not affected by acute antiparkinsonian medication",

abstract = "Objective A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. Methods Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45min after their usual dose of antiparkinsonian medication. OFF-medication, patients were tested after not taking antiparkinsonian medication for >12h. OFF and ON-medication was counter-balanced across subjects. For dMRI, we computed free-water and free-water corrected fractional anisotropy (FAt) within the following regions: caudate, putamen, substantia nigra, and subthalamic nucleus. Results ON-medication significantly reduced parkinsonian motor symptoms compared with OFF-medication (p",

keywords = "dMRI, Parkinson's disease, Antiparkinsonian medication, Free-water, Free-water corrected fractional anisotropy",

author = "Chung, {Jae Woo} and Burciu, {Roxana G.} and Edward Ofori and Priyank Shukla and Okun, {Michael S.} and Hess, {Christopher W.} and Vaillancourt, {David E.}",

year = "2017",

doi = "10.1016/j.nicl.2017.02.012",

language = "English (US)",

volume = "14",

pages = "417--421",

journal = "NeuroImage: Clinical",

issn = "2213-1582",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Parkinson's disease diffusion MRI is not affected by acute antiparkinsonian medication

AU - Chung, Jae Woo

AU - Burciu, Roxana G.

AU - Ofori, Edward

AU - Shukla, Priyank

AU - Okun, Michael S.

AU - Hess, Christopher W.

AU - Vaillancourt, David E.

PY - 2017

Y1 - 2017

N2 - Objective A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. Methods Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45min after their usual dose of antiparkinsonian medication. OFF-medication, patients were tested after not taking antiparkinsonian medication for >12h. OFF and ON-medication was counter-balanced across subjects. For dMRI, we computed free-water and free-water corrected fractional anisotropy (FAt) within the following regions: caudate, putamen, substantia nigra, and subthalamic nucleus. Results ON-medication significantly reduced parkinsonian motor symptoms compared with OFF-medication (p

AB - Objective A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. Methods Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45min after their usual dose of antiparkinsonian medication. OFF-medication, patients were tested after not taking antiparkinsonian medication for >12h. OFF and ON-medication was counter-balanced across subjects. For dMRI, we computed free-water and free-water corrected fractional anisotropy (FAt) within the following regions: caudate, putamen, substantia nigra, and subthalamic nucleus. Results ON-medication significantly reduced parkinsonian motor symptoms compared with OFF-medication (p

KW - dMRI

KW - Parkinson's disease

KW - Antiparkinsonian medication

KW - Free-water

KW - Free-water corrected fractional anisotropy

U2 - 10.1016/j.nicl.2017.02.012

DO - 10.1016/j.nicl.2017.02.012

M3 - Article

C2 - 28275542

SN - 2213-1582

VL - 14

SP - 417

EP - 421

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

ER -

Parkinson's disease diffusion MRI is not affected by acute antiparkinsonian medication

Abstract

Keywords

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