An average 86% increase in parietal cell numbers was found in 19 paired biopsy specimens taken from the dog gastric corpus before and 1 month after the Mann-Williamson operation. In this experimental model it seems likely that exclusion of acid gastric juice from the duodenal lumen results in the loss of inhibitory hormonal control of gastric secretion, and secondarily in parietal cell hyperplasia. Increase of the parietal cell mass has now been induced by several apparently different mechanisms.
Bibliographical noteFunding Information:
Department of Surgery, Mayo Box no. 89, University of Minnesota Hospitals, Health Sciences Center, 412 Union Street S.E., Minneapolis, Minnesota 55455. Supported by U.S.P.H.S. Grant AM-12344. Submitted for publication April 6, 1972.
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