Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated Aβ(1-42) injections

D. G. McDaid, E. M. Kim, R. E. Reid, J. C. Leslie, James P Cleary, E. O'Hare

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

There is evidence that oxidative stress may play a role in the neuropathology of Alzheimer's disease (AD). This study used an aggregated beta-amyloid (Aβ) injection model of AD in the rat, and a recycling conjunctive schedule of food reinforcement to examine the effects of bilateral intrahippocampal injections of aggregated Aβ(1-42) (5.0 μl/side) on temporal discrimination, and the efficacy of the antioxidant α-tocopherol (150 mg/kg daily p.o.) in alleviating these effects. The results indicated that bilateral intrahippocampal injections of aggregated Aβ(1-42) detrimentally affected temporal discrimination from five-day block 31-35 post-injections until the end of the study (90 days post-injections). Daily treatment with α-tocopherol improved temporal discrimination under the recycling conjunctive schedule following aggregated Aβ(1-42) injections from the five-day block 61-65 days until the end of the study.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalBehavioural Pharmacology
Volume16
Issue number4
DOIs
StatePublished - Jul 1 2005

Keywords

  • Antioxidant
  • Operant
  • Rat
  • Reinforcement
  • Schedule

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