TY - JOUR
T1 - Parental age and the risk of childhood acute myeloid leukemia
T2 - results from the Childhood Leukemia International Consortium
AU - FRECCLE group
AU - NARECHEM-ST group
AU - Panagopoulou, Paraskevi
AU - Skalkidou, Alkistis
AU - Marcotte, Erin
AU - Erdmann, Friederike
AU - Ma, Xiaomei
AU - Heck, Julia E.
AU - Auvinen, Anssi
AU - Mueller, Beth A.
AU - Spector, Logan G.
AU - Roman, Eve
AU - Metayer, Catherine
AU - Magnani, Corrado
AU - Pombo-de-Oliveira, Maria S.
AU - Scheurer, Michael E.
AU - Mora, Ana Maria
AU - Dockerty, John D.
AU - Hansen, Johnni
AU - Kang, Alice Y.
AU - Wang, Rong
AU - Doody, David R.
AU - Kane, Eleanor
AU - Schüz, Joachim
AU - Christodoulakis, Christos
AU - Ntzani, Evangelia
AU - Petridou, Eleni Th
N1 - Publisher Copyright:
© 2019
PY - 2019/4
Y1 - 2019/4
N2 - BACKGROUND: Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.AIM: To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.MATERIAL/METHODS: We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.RESULTS: Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.CONCLUSIONS: An increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children.
AB - BACKGROUND: Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.AIM: To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.MATERIAL/METHODS: We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.RESULTS: Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.CONCLUSIONS: An increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children.
KW - Childhood cancer
KW - Epidemiology
KW - Infant acute myeloid leukemia
KW - Maternal age
KW - Paternal age
KW - Risk factors
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U2 - 10.1016/j.canep.2019.01.022
DO - 10.1016/j.canep.2019.01.022
M3 - Article
C2 - 30776582
AN - SCOPUS:85061603212
SN - 1877-7821
VL - 59
SP - 158
EP - 165
JO - Cancer Epidemiology
JF - Cancer Epidemiology
ER -
