Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium

FRECCLE group, NARECHEM-ST group

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

BACKGROUND: Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.

AIM: To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.

MATERIAL/METHODS: We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.

RESULTS: Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.

CONCLUSIONS: An increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children.

Original languageEnglish (US)
Pages (from-to)158-165
Number of pages8
JournalCancer Epidemiology
Volume59
DOIs
StatePublished - Apr 2019

Bibliographical note

Publisher Copyright:
© 2019

Keywords

  • Childhood cancer
  • Epidemiology
  • Infant acute myeloid leukemia
  • Maternal age
  • Paternal age
  • Risk factors

PubMed: MeSH publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Journal Article
  • Research Support, N.I.H., Extramural

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