Parental Age and Risk of Infant Leukaemia: A Pooled Analysis

Erin L. Marcotte, Todd E. Druley, Kimberly J. Johnson, Michaela Richardson, Julie von Behren, Beth A. Mueller, Susan Carozza, Colleen McLaughlin, Eric J. Chow, Peggy Reynolds, Logan G. Spector

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Infant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL. Methods: We evaluated the relationship between parental age and IL in a case–control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases [219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45 392 controls born during 1981–2004 were analysed. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively. Results: Infants with mothers' age ≥40 years had an increased risk of developing AML (OR 4.80, 95% CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95% CI 1.62, 8.41). Conclusion: This study demonstrates increased risk of infant ALL in relation to young paternal age. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations, and/or carcinogenic exposures may be involved in IL aetiology.

Original languageEnglish (US)
Pages (from-to)563-572
Number of pages10
JournalPaediatric and perinatal epidemiology
Volume31
Issue number6
DOIs
StatePublished - Nov 2017

Fingerprint

Leukemia
Parents
Paternal Age
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Odds Ratio
Confidence Intervals
Acute Myeloid Leukemia
Mutation
Mothers
Selection Bias
Maternal Age
Registries
Logistic Models
Parturition
Genes
Neoplasms

Keywords

  • childhood cancer
  • epidemiology
  • infant leukaemia
  • maternal age
  • paternal age

Cite this

Parental Age and Risk of Infant Leukaemia : A Pooled Analysis. / Marcotte, Erin L.; Druley, Todd E.; Johnson, Kimberly J.; Richardson, Michaela; von Behren, Julie; Mueller, Beth A.; Carozza, Susan; McLaughlin, Colleen; Chow, Eric J.; Reynolds, Peggy; Spector, Logan G.

In: Paediatric and perinatal epidemiology, Vol. 31, No. 6, 11.2017, p. 563-572.

Research output: Contribution to journalArticle

Marcotte, EL, Druley, TE, Johnson, KJ, Richardson, M, von Behren, J, Mueller, BA, Carozza, S, McLaughlin, C, Chow, EJ, Reynolds, P & Spector, LG 2017, 'Parental Age and Risk of Infant Leukaemia: A Pooled Analysis', Paediatric and perinatal epidemiology, vol. 31, no. 6, pp. 563-572. https://doi.org/10.1111/ppe.12412
Marcotte, Erin L. ; Druley, Todd E. ; Johnson, Kimberly J. ; Richardson, Michaela ; von Behren, Julie ; Mueller, Beth A. ; Carozza, Susan ; McLaughlin, Colleen ; Chow, Eric J. ; Reynolds, Peggy ; Spector, Logan G. / Parental Age and Risk of Infant Leukaemia : A Pooled Analysis. In: Paediatric and perinatal epidemiology. 2017 ; Vol. 31, No. 6. pp. 563-572.
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abstract = "Background: Infant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL. Methods: We evaluated the relationship between parental age and IL in a case–control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases [219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45 392 controls born during 1981–2004 were analysed. Odds ratios (OR) and 95{\%} confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively. Results: Infants with mothers' age ≥40 years had an increased risk of developing AML (OR 4.80, 95{\%} CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95{\%} CI 1.62, 8.41). Conclusion: This study demonstrates increased risk of infant ALL in relation to young paternal age. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations, and/or carcinogenic exposures may be involved in IL aetiology.",
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T1 - Parental Age and Risk of Infant Leukaemia

T2 - A Pooled Analysis

AU - Marcotte, Erin L.

AU - Druley, Todd E.

AU - Johnson, Kimberly J.

AU - Richardson, Michaela

AU - von Behren, Julie

AU - Mueller, Beth A.

AU - Carozza, Susan

AU - McLaughlin, Colleen

AU - Chow, Eric J.

AU - Reynolds, Peggy

AU - Spector, Logan G.

PY - 2017/11

Y1 - 2017/11

N2 - Background: Infant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL. Methods: We evaluated the relationship between parental age and IL in a case–control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases [219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45 392 controls born during 1981–2004 were analysed. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively. Results: Infants with mothers' age ≥40 years had an increased risk of developing AML (OR 4.80, 95% CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95% CI 1.62, 8.41). Conclusion: This study demonstrates increased risk of infant ALL in relation to young paternal age. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations, and/or carcinogenic exposures may be involved in IL aetiology.

AB - Background: Infant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL. Methods: We evaluated the relationship between parental age and IL in a case–control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases [219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45 392 controls born during 1981–2004 were analysed. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively. Results: Infants with mothers' age ≥40 years had an increased risk of developing AML (OR 4.80, 95% CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95% CI 1.62, 8.41). Conclusion: This study demonstrates increased risk of infant ALL in relation to young paternal age. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations, and/or carcinogenic exposures may be involved in IL aetiology.

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KW - paternal age

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