Parcellation in left lateral parietal cortex is similar in adults and children

Kelly Anne Barnes, Steven M. Nelson, Alexander L. Cohen, Jonathan D. Power, Rebecca S. Coalson, Francis M. Miezin, Alecia C. Vogel, Joseph W. Dubis, Jessica A. Church, Steven E. Petersen, Bradley L. Schlaggar

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A key question in developmental neuroscience involves understanding how and when the cerebral cortex is partitioned into distinct functional areas. The present study used functional connectivity MRI mapping and graph theory to identify putative cortical areas and generate a parcellation scheme of left lateral parietal cortex (LLPC) in 7 to 10-year-old children and adults. Results indicated that a majority of putative LLPC areas could be matched across groups (mean distance between matched areas across age: 3.15 mm). Furthermore, the boundaries of children's putative LLPC areas respected the boundaries generated from the adults' parcellation scheme for a majority of children's areas (13/15). Consistent with prior research, matched LLPC areas showed age-related differences in functional connectivity strength with other brain regions. These results suggest that LLPC cortical parcellation and functional connectivity mature along different developmental trajectories, with adult-like boundaries between LLPC areas established in school-age children prior to adult-like functional connectivity.

Original languageEnglish (US)
Pages (from-to)1148-1158
Number of pages11
JournalCerebral Cortex
Issue number5
StatePublished - May 2012
Externally publishedYes

Bibliographical note

Funding Information:
National Institutes of Health (grants NS007205-28 to K.A.B., NS062489 to A.L.C., NS053425, HD057076, and MH091512 to B.L.S., and NS06114 and NS046424 to S.E.P.); Simons Foundation Autism Research Initiative.


  • brain development
  • functional areas
  • functional connectivity
  • parietal lobe


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