Abstract
Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 625-630 |
| Number of pages | 6 |
| Journal | Annals of Neurology |
| Volume | 51 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2002 |
UN SDGs
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SDG 3 Good Health and Well-being
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