Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma

Steven Vernino, Paul Tuite, Charles H. Adler, James F. Meschia, Bradley F. Boeve, Peter Boasberg, Joseph E. Parisi, Vanda A. Lennon

Research output: Contribution to journalArticlepeer-review

193 Scopus citations


Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalAnnals of Neurology
Issue number5
StatePublished - 2002


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