Parametric Spatial Cure Rate Models for Interval-Censored Time-to-Relapse Data

Sudipto Banerjee, Brad Carlin

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Several recent papers (e.g., Chen, Ibrahim, and Sinha, 1999, Journal of the American Statistical Association 94, 909-919; Ibrahim, Chen, and Sinha, 2001a, Biometrics 57, 383-388) have described statistical methods for use with time-to-event data featuring a surviving fraction (i.e., a proportion of the population that never experiences the event). Such cure rate models and their multivariate generalizations are quite useful in studies of multiple diseases to which an individual may never succumb, or from which an individual may reasonably be expected to recover following treatment (e.g., various types of cancer). In this article we extend these models to allow for spatial correlation (estimable via zip code identifiers for the subjects) as well as interval censoring. Our approach is Bayesian, where posterior summaries are obtained via a hybrid Markov chain Monte Carlo algorithm. We compare across a broad collection of rather high-dimensional hierarchical models using the deviance information criterion, a tool recently developed for just this purpose. We apply our approach to the analysis of a smoking cessation study where the subjects reside in 53 southeastern Minnesota zip codes. In addition to the usual posterior estimates, our approach yields smoothed zip code level maps of model parameters related to the relapse rates over time and the ultimate proportion of quitters (the cure rates).

Original languageEnglish (US)
Pages (from-to)268-275
Number of pages8
JournalBiometrics
Volume60
Issue number1
DOIs
StatePublished - Mar 2004

Keywords

  • Bayesian analysis
  • Conditionally autoregressive prior
  • Deviance information criterion
  • Markov chain Monte Carlo methods
  • Smoking cessation

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