Purpose: To develop a 3D composite adiabatic spectral-spatial pulse for refocusing in spin-echo spectroscopy acquisitions and to compare its performance against standard acquisition methods. Methods: A 3D composite adiabatic pulse was designed by modulating a train of parallel transmit–optimized 2D subpulses with an adiabatic envelope. The spatial and spectral profiles were simulated and validated by experiments to demonstrate the feasibility of the design in both single and double spin-echo spectroscopy acquisitions. Phantom and in vivo studies were performed to evaluate the pulse performance and compared with semi-LASER with respect to localization performance, sequence timing, signal suppression, and specific absorption rate. Results: Simultaneous 2D spatial localization with water and lipid suppression was achieved with the designed refocusing pulse, allowing high-quality spectra to be acquired with shorter minimum TE/TR, reduced SAR, as well as adaptation to spatially varying B0 and (Formula presented.) field inhomogeneities in both prostate and brain studies. Conclusion: The proposed composite pulse can serve as a more SAR efficient alternative to conventional localization methods such as semi-LASER at ultrahigh field for spin echo–based spectroscopy studies. Subpulse parallel-transmit optimization provides the flexibility to manage the tradeoff among multiple design criteria to accommodate different field strengths and applications.
Bibliographical noteFunding Information:
National Institute of Biomedical Imaging and Bioengineering; Grant/Award No. P41 EB027061 The authors thank Malgorzata Marjanska and Patrick Bolan for the insightful discussion and suggestions, as well as support from G?lin ?z and James M. Joers.
© 2021 International Society for Magnetic Resonance in Medicine
- RF pulse design
- magnetic resonance spectroscopy
- parallel transmission
- ultrahigh-field imaging
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural