Parallel-transmission spatial spectral pulse design with local specific absorption rate control: Demonstration for robust uniform water-selective excitation in the human brain at 7 T

Purpose: To propose a novel method for parallel-transmission (pTx) spatial-spectral pulse design and demonstrate its utility for robust uniform water-selective excitation (water excitation) across the entire brain. Theory and Methods: Our design problem is formulated as a magnitude-least-squares minimization with joint RF and k-space optimization under explicit specific-absorption-rate constraints. For improved robustness against off-resonance effects, the spectral component of the excitation target is prescribed to have a water passband and a fat stopband. A two-step algorithm was devised to solve our design problem, with Step 1 aiming to solve a reduced problem to find a sensible start point for Step 2 to solve the original problem. The efficacy of our pulse design was evaluated in simulation, phantom, and human experiments using the commercial Nova head coil. Universal pulses were also designed based on a 10-subject training data set to demonstrate the utility of our method for plug-and-play pTx. Results: For k_T-points and spiral nonselective parameterizations, our design method outperformed the pTx interleaved binomial approach, reducing RMS error by up to about 35% for water excitation and about 97% for fat suppression (over a 200-Hz bandwidth) while decreasing local specific absorption rate by about 30%. Both our subject-specific and universal pulses improved water excitation, restoring signal loss in the cerebellum while suppressing fat signal even in regions of large susceptibility-induced off-resonances. Conclusion: Demonstrated useful for 4D (3D spatial, one-dimensional spectral) pTx spatial-spectral pulse design, our proposed method provides an effective solution for robust volumetric uniform water excitation, holding a promise to many ultrahigh-field applications.