Parallel hippocampal-parietal circuits for self- And goal-oriented processing

Annie Zheng, David F. Montez, Scott Marek, Adrian W. Gilmore, Dillan J. Newbold, Timothy O. Laumann, Benjamin P. Kay, Nicole A. Seider, Andrew N. Van, Jacqueline M. Hampton, Dimitrios Alexopoulos, Bradley L. Schlaggar, Chad M. Sylvester, Deanna J. Greene, Joshua S. Shimony, Steven M. Nelson, Gagan S. Wig, Caterina Gratton, Kathleen B. McDermott, Marcus E. RaichleEvan M. Gordon, Nico U.F. Dosenbach

Research output: Contribution to journalArticlepeer-review

Abstract

The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior–posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing.

Original languageEnglish (US)
Article numbere2101743118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number34
DOIs
StatePublished - Aug 24 2021

Bibliographical note

Funding Information:
This work was supported by NIH Grant Nos. NS115672 and MH123091 (A.Z.); NS088590, MH096773, MH124567, MH122066, and MH121276 (N.U.F.D.); MH118370 and pilot funding support from the Northwestern Alzheimer?s Disease Center NIA P30AG13854 (C.G.); MH122389 and MH109983 (C.M.S.); HD087011 (J.S.S.); NS110332 (D.J.N.); and MH121518 (S.M.); and funds provided by the Kiwanis Neuroscience Research Foundation (N.U.F.D.), the Jacobs Foundation (N.U.F.D.), and the McDonnell Center for Systems Neuroscience at Washington University in St. Louis (A.Z., N.U.F.D., and D.J.N).

Funding Information:
ACKNOWLEDGMENTS. This work was supported by NIH Grant Nos. NS115672 and MH123091 (A.Z.); NS088590, MH096773, MH124567, MH122066, and MH121276 (N.U.F.D.); MH118370 and pilot funding support from the North-western Alzheimer’s Disease Center NIA P30AG13854 (C.G.); MH122389 and MH109983 (C.M.S.); HD087011 (J.S.S.); NS110332 (D.J.N.); and MH121518 (S.M.); and funds provided by the Kiwanis Neuroscience Research Foundation (N.U.F.D.), the Jacobs Foundation (N.U.F.D.), and the McDonnell Center for Systems Neuroscience at Washington University in St. Louis (A.Z., N.U.F.D., and D.J.N).

Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.

Keywords

  • Brain networks
  • Functional connectivity
  • Hippocampus
  • Individual variability
  • Resting state

Fingerprint

Dive into the research topics of 'Parallel hippocampal-parietal circuits for self- And goal-oriented processing'. Together they form a unique fingerprint.

Cite this