PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE

R. Paul Robertson; William R. Hazzard; John D. Brunzell; Roger L. Lerner; Daniel Porte

doi:10.1016/S0140-6736(72)92146-0

PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE

R. Paul Robertson, William R. Hazzard, John D. Brunzell, Roger L. Lerner, Daniel Porte

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

After the stress of a drug reaction, a previously non-diabetic subject had a unique, paradoxical decrease in circulating insulin in response to intravenous glucose. This response disappeared during α-adrenergic blockade with phentolamine and could be reproduced by α stimulation with adrenaline. It was concluded that the α receptor, possibly stimulated by endogenous catecholamine release in response to glucose, played a role in this unusual example of abnormal insulin secretion.

Original language	English (US)
Pages (from-to)	787-789
Number of pages	3
Journal	The Lancet
Volume	300
Issue number	7781
DOIs	https://doi.org/10.1016/S0140-6736(72)92146-0
State	Published - Oct 14 1972
Externally published	Yes

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title = "PARADOXICAL HYPOINSULIN{\AE}MIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE",

abstract = "After the stress of a drug reaction, a previously non-diabetic subject had a unique, paradoxical decrease in circulating insulin in response to intravenous glucose. This response disappeared during α-adrenergic blockade with phentolamine and could be reproduced by α stimulation with adrenaline. It was concluded that the α receptor, possibly stimulated by endogenous catecholamine release in response to glucose, played a role in this unusual example of abnormal insulin secretion.",

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AU - Robertson, R. Paul

AU - Hazzard, William R.

AU - Brunzell, John D.

AU - Lerner, Roger L.

AU - Porte, Daniel

PY - 1972/10/14

Y1 - 1972/10/14

N2 - After the stress of a drug reaction, a previously non-diabetic subject had a unique, paradoxical decrease in circulating insulin in response to intravenous glucose. This response disappeared during α-adrenergic blockade with phentolamine and could be reproduced by α stimulation with adrenaline. It was concluded that the α receptor, possibly stimulated by endogenous catecholamine release in response to glucose, played a role in this unusual example of abnormal insulin secretion.

AB - After the stress of a drug reaction, a previously non-diabetic subject had a unique, paradoxical decrease in circulating insulin in response to intravenous glucose. This response disappeared during α-adrenergic blockade with phentolamine and could be reproduced by α stimulation with adrenaline. It was concluded that the α receptor, possibly stimulated by endogenous catecholamine release in response to glucose, played a role in this unusual example of abnormal insulin secretion.

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ER -

PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE

Abstract

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