PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE

R. Paul Robertson, William R. Hazzard, John D. Brunzell, Roger L. Lerner, Daniel Porte

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

After the stress of a drug reaction, a previously non-diabetic subject had a unique, paradoxical decrease in circulating insulin in response to intravenous glucose. This response disappeared during α-adrenergic blockade with phentolamine and could be reproduced by α stimulation with adrenaline. It was concluded that the α receptor, possibly stimulated by endogenous catecholamine release in response to glucose, played a role in this unusual example of abnormal insulin secretion.

Original languageEnglish (US)
Pages (from-to)787-789
Number of pages3
JournalThe Lancet
Volume300
Issue number7781
DOIs
StatePublished - Oct 14 1972
Externally publishedYes

Fingerprint

Dive into the research topics of 'PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE'. Together they form a unique fingerprint.

Cite this