PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE

R. Paul Robertson, William R. Hazzard, John D. Brunzell, Roger L. Lerner, Daniel Porte

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

After the stress of a drug reaction, a previously non-diabetic subject had a unique, paradoxical decrease in circulating insulin in response to intravenous glucose. This response disappeared during α-adrenergic blockade with phentolamine and could be reproduced by α stimulation with adrenaline. It was concluded that the α receptor, possibly stimulated by endogenous catecholamine release in response to glucose, played a role in this unusual example of abnormal insulin secretion.

Original languageEnglish (US)
Pages (from-to)787-789
Number of pages3
JournalThe Lancet
Volume300
Issue number7781
DOIs
StatePublished - Oct 14 1972

Fingerprint Dive into the research topics of 'PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE'. Together they form a unique fingerprint.

  • Cite this

    Robertson, R. P., Hazzard, W. R., Brunzell, J. D., Lerner, R. L., & Porte, D. (1972). PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE. The Lancet, 300(7781), 787-789. https://doi.org/10.1016/S0140-6736(72)92146-0