Remarkable efforts have been dedicated to paper-based chemosensors and biosensors over the last few years, mainly driven by the promise of reaching the best trade-off between performance, affordability and simplicity. Because of the low-cost and rapid prototyping of these sensors, recent research has been focused on providing affordable diagnostic devices to the developing world. The recent progress in sensitivity, multi-functionality and integration of microfluidic paper-based analytical devices (μPADs), increasingly suggests that this technology is not only attractive in resource-limited environments but it also represents a serious challenger to silicon, glass and polymer-based biosensors. This review discusses the design, chemistry and engineering aspects of these developments, with a focus on the past few years.
Bibliographical noteFunding Information:
Our research in the area of paper-based chemical sensing and biosensing is supported by the University of Minnesota MnDRIVE Global Food Venture and the USDA National Institute of Food and Agriculture, Hatch project 1006789.
- Cellulose paper
- Lateral flow assays
- Paper microfluidics