Pantocin A, a peptide-derived antibiotic involved in biological control by plant-associated Pantoea species

Theo H.M. Smits, Brion Duffy, Jochen Blom, Carol A. Ishimaru, Virginia O. Stockwell

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The genus Pantoea contains a broad range of plant-associated bacteria, including some economically important plant pathogens as well as some beneficial members effective as biological control agents of plant pathogens. The most well-characterized representatives of biological control agents from this genus generally produce one or more antimicrobial compounds adding to biocontrol efficacy. Some Pantoea species evaluated as biocontrol agents for fire blight disease of apple and pear produce a histidine-reversible antibiotic. Three commonly studied histidine-reversible antibiotics produced by Pantoea spp. are herbicolin O, MccEh252, and pantocin A. Pantocin A is a novel ribosomally encoded and post-translationally modified peptide natural product. Here, we review the current knowledge on the chemistry, genetics, biosynthesis, and incidence and environmental relevance of pantocin A and related histidine-reversible antibiotics produced by Pantoea.

Original languageEnglish (US)
Pages (from-to)713-722
Number of pages10
JournalArchives of Microbiology
Volume201
Issue number6
DOIs
StatePublished - Aug 1 2019

Keywords

  • Biocontrol
  • Erwinia amylovora
  • Fire blight
  • Herbicolin O
  • Histidine-reversible
  • MccEh252
  • Pantoea agglomerans
  • Pantoea vagans

PubMed: MeSH publication types

  • Journal Article
  • Review

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