Objectives: To update the medical literature on recent cellular and molecular advances in otitis media disease models with a principal focus on developments in the past 5 years. We also aim to explain recent translational advances in cellular and molecular biology that have influenced our understanding and management of otitis media. Data Sources: PubMed-indexed peer-reviewed articles. Review Methods: A comprehensive review of the literature was conducted with the term otitis media and the following search terms: molecular biology, cell biology, innate immunity, oxidative stress, mucins, molecular diagnostics. Included articles were published in the English language from January 1, 2010, to July 31, 2015. Implications for Practice: The molecular understanding of otitis media disease progression has rapidly advanced over the last 5 years. The roles of inflammation, mucins, and cell signaling mechanisms have been elucidated and defined. Advances in the field provide a plethora of opportunities for innovative molecular targeting in the development of novel therapeutic strategies for otitis media.
|Original language||English (US)|
|Journal||Otolaryngology - Head and Neck Surgery (United States)|
|State||Published - Apr 1 2017|
Bibliographical notePublisher Copyright:
© American Academy of Otolaryngology—Head and Neck Surgery Foundation 2017.
- Toll-like receptors
- cell biology
- innate immunity
- molecular biology
- molecular diagnostics
- optical coherence tomography
- otitis media
- oxidative stress