Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal

Fabrizis Suarez, Michael D. Levitt, Jacqueline Adshead, Jamie S. Barkin

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

In a double-blind, crossover study, we determined whether microencapusulated pancreatic enzymes reduce postprandial symptoms experienced by healthy volunteers after ingestion of a high calorie, high fat meal. At 7 AM, 18 subjects ingested 185 g of cookies (1196 calories and 72 g of fat) with three pancrelipase capsules or a placebo. The severity of gastrointestinal symptoms and flatus passages were recorded for 15-17 hr, and end-alveolar samples were obtained hourly for 10 hr. Ingestion of pancreatic supplements was associated with a significant (P = 0.049) reduction in bloating over the entire recording period, and with significant reductions in bloating, gas, and fullness during the dinner to bedtime period. Pancreatic supplements had no significant effect on breath H2 or CH4 concentration. The finding that pancreatic supplements reduce postprandial symptoms in healthy subjects suggests that these supplements also might be beneficial in irritable bowel syndrome.

Original languageEnglish (US)
Pages (from-to)1317-1321
Number of pages5
JournalDigestive Diseases and Sciences
Volume44
Issue number7
DOIs
StatePublished - Sep 3 1999

Keywords

  • Breath hydrogen
  • Gastrointestinal symptoms
  • Pancreatic enzymes

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