Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal

Fabrizis Suarez, Michael D. Levitt, Jacqueline Adshead, Jamie S. Barkin

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38 Scopus citations


In a double-blind, crossover study, we determined whether microencapusulated pancreatic enzymes reduce postprandial symptoms experienced by healthy volunteers after ingestion of a high calorie, high fat meal. At 7 AM, 18 subjects ingested 185 g of cookies (1196 calories and 72 g of fat) with three pancrelipase capsules or a placebo. The severity of gastrointestinal symptoms and flatus passages were recorded for 15-17 hr, and end-alveolar samples were obtained hourly for 10 hr. Ingestion of pancreatic supplements was associated with a significant (P = 0.049) reduction in bloating over the entire recording period, and with significant reductions in bloating, gas, and fullness during the dinner to bedtime period. Pancreatic supplements had no significant effect on breath H2 or CH4 concentration. The finding that pancreatic supplements reduce postprandial symptoms in healthy subjects suggests that these supplements also might be beneficial in irritable bowel syndrome.

Original languageEnglish (US)
Pages (from-to)1317-1321
Number of pages5
JournalDigestive Diseases and Sciences
Issue number7
StatePublished - 1999

Bibliographical note

Funding Information:
Supported in part by research funds from the De partme nt of Veterans Affairs, the National Institute of Diabete s and Digestive and Kidney Diseases (R01-D1309K3-25) , and Solvay Pharmaceutical Inc., Marietta, Georgia.


  • Breath hydrogen
  • Gastrointestinal symptoms
  • Pancreatic enzymes


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