Pancreatic islets seeded in a novel bioscaffold forms an organoid to rescue insulin production and reverse hyperglycemia in models of type 1 diabetes

Keyphrases

• Type I Diabetes 100%
• Type 1 Diabetes Mellitus (T1DM) 100%
• Pancreatic Islets 100%
• Hyperglycemia 100%
• Organoids 100%
• Insulin Production 100%
• Bioscaffold 100%
• Biomaterials 75%
• Islet 50%
• Exogenous Insulin 50%
• Insulin Administration 50%
• Opportunistic Infections 25%
• Immunosuppression 25%
• Therapeutic Approaches 25%
• Insulin 25%
• Diabetic 25%
• Clinical Application 25%
• Syngeneic 25%
• Extracellular Matrix 25%
• Substructure 25%
• Metabolic Indices 25%
• Copolymer 25%
• Long-term Viability 25%
• Tissue Regeneration 25%
• Microenvironment 25%
• Diabetic Mice 25%
• Cationic Polymer 25%
• Extracellular Signaling 25%
• Streptozotocin-induced 25%
• Immunosuppressive Therapy 25%
• Improved Survival 25%
• Disease States 25%
• Glucose Level 25%
• Blood Glucose 25%
• Soluble Factors 25%
• Organ Function 25%
• Insulin Level 25%
• Pancreas Transplantation 25%
• Neovascularization 25%
• Polymeric Biomaterials 25%
• Endothelial Progenitors 25%
• Diabetic Mouse Model 25%
• Insufficient Tissue 25%
• Pancreatic Islet Cells 25%
• Non-obese Diabetic Mice 25%
• Donor Side 25%

Medicine and Dentistry

• Insulin Dependent Diabetes Mellitus 100%
• Pancreatic Islet 100%
• Organoid 100%
• Hyperglycemia 100%
• Biocompatible Material 100%
• Immunosuppressive Treatment 50%
• Disease 25%
• Opportunistic Infection 25%
• Pancreas Transplantation 25%
• Extracellular Matrix 25%
• Diabetes Mellitus 25%
• Side Effect 25%
• Streptozocin 25%
• Cell Viability 25%
• Copolymer 25%
• Tissue Regeneration 25%
• Blood Glucose 25%
• Ob/Ob Mouse 25%