Pancreatic islet xenotransplantation

Melanie L. Graham; Henk Jan Schuurman

doi:10.1016/j.ddmod.2017.11.004

Pancreatic islet xenotransplantation

Melanie L. Graham
, Henk Jan Schuurman

Surgery

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (3) features in this animal model that are relevant for clinical development; and (4) limitations and translational value of the model in nonhuman primates.

Original language	English (US)
Pages (from-to)	43-50
Number of pages	8
Journal	Drug Discovery Today: Disease Models
Volume	23
DOIs	https://doi.org/10.1016/j.ddmod.2017.11.004
State	Published - Mar 1 2017

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10.1016/j.ddmod.2017.11.004

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title = "Pancreatic islet xenotransplantation",

abstract = "This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (3) features in this animal model that are relevant for clinical development; and (4) limitations and translational value of the model in nonhuman primates.",

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AB - This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (3) features in this animal model that are relevant for clinical development; and (4) limitations and translational value of the model in nonhuman primates.

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JO - Drug Discovery Today: Disease Models

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ER -

Pancreatic islet xenotransplantation

Abstract

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