Pancreatic Islet Cell Carcinoma With Gastrin and Vasoactive Intestinal Polypeptide Production

Thomas P. Barragry, Mark R. Wick, John P Delaney

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

• The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.

Original languageEnglish (US)
Pages (from-to)1178-1181
Number of pages4
JournalArchives of Surgery
Volume120
Issue number10
DOIs
StatePublished - Oct 1985

Fingerprint Dive into the research topics of 'Pancreatic Islet Cell Carcinoma With Gastrin and Vasoactive Intestinal Polypeptide Production'. Together they form a unique fingerprint.

Cite this