Pancreas Transplantation and Reversal of Diabetic Nephropathy Lesions

Michael Mauer, Paola Fioretto

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalMedical Clinics of North America
Volume97
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Diabetic glomerular lesions
  • Diabetic nephropathy
  • Pancreas transplantation
  • Reversal healing
  • Type 1 diabetes

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