Pancreas Transplantation and Reversal of Diabetic Nephropathy Lesions

Michael Mauer, Paola Fioretto

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalMedical Clinics of North America
Volume97
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Pancreas Transplantation
Diabetic Nephropathies
Type 1 Diabetes Mellitus
Hypoglycemia
Kidney
Therapeutics

Keywords

  • Diabetic glomerular lesions
  • Diabetic nephropathy
  • Pancreas transplantation
  • Reversal healing
  • Type 1 diabetes

Cite this

Pancreas Transplantation and Reversal of Diabetic Nephropathy Lesions. / Mauer, Michael; Fioretto, Paola.

In: Medical Clinics of North America, Vol. 97, No. 1, 01.01.2013, p. 109-114.

Research output: Contribution to journalReview article

@article{d92d98c4e1e244349aa5d4eee1f0bd04,
title = "Pancreas Transplantation and Reversal of Diabetic Nephropathy Lesions",
abstract = "Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.",
keywords = "Diabetic glomerular lesions, Diabetic nephropathy, Pancreas transplantation, Reversal healing, Type 1 diabetes",
author = "Michael Mauer and Paola Fioretto",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.mcna.2012.10.009",
language = "English (US)",
volume = "97",
pages = "109--114",
journal = "Medical Clinics of North America",
issn = "0025-7125",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Pancreas Transplantation and Reversal of Diabetic Nephropathy Lesions

AU - Mauer, Michael

AU - Fioretto, Paola

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.

AB - Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.

KW - Diabetic glomerular lesions

KW - Diabetic nephropathy

KW - Pancreas transplantation

KW - Reversal healing

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84871723545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871723545&partnerID=8YFLogxK

U2 - 10.1016/j.mcna.2012.10.009

DO - 10.1016/j.mcna.2012.10.009

M3 - Review article

C2 - 23290733

AN - SCOPUS:84871723545

VL - 97

SP - 109

EP - 114

JO - Medical Clinics of North America

JF - Medical Clinics of North America

SN - 0025-7125

IS - 1

ER -