Palladium catalyzed intramolecular acylcyanation of alkenes using α-iminonitriles

Naveen R. Rondla, Jodi M. Ogilvie, Zhongda Pan, Christopher J. Douglas

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Abstract

Reported here is a palladium catalyzed intramolecular acylcyanation of alkenes using α-iminonitriles. Through this method, highly functionalized indanones are synthesized in moderate to high yields using Pd(PPh3)4, without need for any additional ligands, and a common Lewis acid (ZnCl2). Additionally, the reaction tolerates substitution at various positions on the aromatic ring including electron donating and electron withdrawing groups.

Original languageEnglish (US)
Pages (from-to)8974-8977
Number of pages4
JournalChemical Communications
Volume50
Issue number64
DOIs
StatePublished - Jul 15 2014

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