Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines

Jiaan Shao; Wenteng Chen; Marc A. Giulianotti; Richard A. Houghten; Yongping Yu

doi:10.1021/ol302533w

Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines

Jiaan Shao, Wenteng Chen, Marc A. Giulianotti, Richard A. Houghten, Yongping Yu

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37 Scopus citations

Abstract

Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination, respectively.

Original language	English (US)
Pages (from-to)	5452-5455
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	21
DOIs	https://doi.org/10.1021/ol302533w
State	Published - Nov 2 2012
Externally published	Yes

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10.1021/ol302533w

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title = "Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines",

abstract = "Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination, respectively.",

author = "Jiaan Shao and Wenteng Chen and Giulianotti, {Marc A.} and Houghten, {Richard A.} and Yongping Yu",

year = "2012",

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doi = "10.1021/ol302533w",

language = "English (US)",

volume = "14",

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journal = "Organic Letters",

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T1 - Palladium-catalyzed C-H functionalization using guanidine as a directing group

T2 - Ortho arylation and olefination of arylguanidines

AU - Shao, Jiaan

AU - Chen, Wenteng

AU - Giulianotti, Marc A.

AU - Houghten, Richard A.

AU - Yu, Yongping

PY - 2012/11/2

Y1 - 2012/11/2

N2 - Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination, respectively.

AB - Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination, respectively.

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U2 - 10.1021/ol302533w

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SN - 1523-7060

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JO - Organic Letters

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ER -

Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines

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