Paired pre-and post-treatment serum biochemical parameters and thyroxine concentrations in a cohort of ninety seven radioiodine-treated hyperthyroid cats

Daniel A Feeney, Carl R. Jessen, Ralph C. Weichselbaum

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2 Citations (Scopus)

Abstract

Serum hepatic and renal parameters from a 97 hyperthyroid cat cohort, sampled within 2 weeks before and 8-11 weeks after oral radioiodine treatment, were retrospectively reviewed for: 1.relationships between pre-treatment total serum thyroxine concentration (T4) and the biochemical values; 2. degree of value change; and 3. influence of pre-treatment methimazole exposure or concurrent cardiac management drugs on the values. Spearmen's ranked correlation, chi-square, Kruskal-Wallis, and Mann-Whitney techniques were used. Weak statistically significant correlations between the pre-treatment T4 and the degree of ALP, ALT, and AST abnormality and between the degree of post-treatment T4, ALP, and ALT reduction were found. The degree of T4 change was greater in methimazole-exposed and cardiac drug-treated cats. The BUN and creatinine significantly increased post-treatment; about half of the cats became azotemic (varying degrees). No significant relationship was found between the pre-treatment T4 or the T4 reduction and the increase in BUN and creatinine values.

Original languageEnglish (US)
Pages (from-to)40-51
Number of pages12
JournalInternational Journal of Applied Research in Veterinary Medicine
Volume9
Issue number1-2
StatePublished - Dec 1 2009

Fingerprint

blood chemistry
L-thyroxine
Hyperthyroidism
thyroxine
Thyroxine
Methimazole
Cats
Blood Urea Nitrogen
cats
Creatinine
pretreatment
Serum
Pharmaceutical Preparations
creatinine
Kidney
drugs
Liver
mouth
kidneys
liver

Keywords

  • Clinical chemistry
  • Hepatic disease
  • Hyperthyroidism
  • Renal function

Cite this

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abstract = "Serum hepatic and renal parameters from a 97 hyperthyroid cat cohort, sampled within 2 weeks before and 8-11 weeks after oral radioiodine treatment, were retrospectively reviewed for: 1.relationships between pre-treatment total serum thyroxine concentration (T4) and the biochemical values; 2. degree of value change; and 3. influence of pre-treatment methimazole exposure or concurrent cardiac management drugs on the values. Spearmen's ranked correlation, chi-square, Kruskal-Wallis, and Mann-Whitney techniques were used. Weak statistically significant correlations between the pre-treatment T4 and the degree of ALP, ALT, and AST abnormality and between the degree of post-treatment T4, ALP, and ALT reduction were found. The degree of T4 change was greater in methimazole-exposed and cardiac drug-treated cats. The BUN and creatinine significantly increased post-treatment; about half of the cats became azotemic (varying degrees). No significant relationship was found between the pre-treatment T4 or the T4 reduction and the increase in BUN and creatinine values.",
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AU - Jessen, Carl R.

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N2 - Serum hepatic and renal parameters from a 97 hyperthyroid cat cohort, sampled within 2 weeks before and 8-11 weeks after oral radioiodine treatment, were retrospectively reviewed for: 1.relationships between pre-treatment total serum thyroxine concentration (T4) and the biochemical values; 2. degree of value change; and 3. influence of pre-treatment methimazole exposure or concurrent cardiac management drugs on the values. Spearmen's ranked correlation, chi-square, Kruskal-Wallis, and Mann-Whitney techniques were used. Weak statistically significant correlations between the pre-treatment T4 and the degree of ALP, ALT, and AST abnormality and between the degree of post-treatment T4, ALP, and ALT reduction were found. The degree of T4 change was greater in methimazole-exposed and cardiac drug-treated cats. The BUN and creatinine significantly increased post-treatment; about half of the cats became azotemic (varying degrees). No significant relationship was found between the pre-treatment T4 or the T4 reduction and the increase in BUN and creatinine values.

AB - Serum hepatic and renal parameters from a 97 hyperthyroid cat cohort, sampled within 2 weeks before and 8-11 weeks after oral radioiodine treatment, were retrospectively reviewed for: 1.relationships between pre-treatment total serum thyroxine concentration (T4) and the biochemical values; 2. degree of value change; and 3. influence of pre-treatment methimazole exposure or concurrent cardiac management drugs on the values. Spearmen's ranked correlation, chi-square, Kruskal-Wallis, and Mann-Whitney techniques were used. Weak statistically significant correlations between the pre-treatment T4 and the degree of ALP, ALT, and AST abnormality and between the degree of post-treatment T4, ALP, and ALT reduction were found. The degree of T4 change was greater in methimazole-exposed and cardiac drug-treated cats. The BUN and creatinine significantly increased post-treatment; about half of the cats became azotemic (varying degrees). No significant relationship was found between the pre-treatment T4 or the T4 reduction and the increase in BUN and creatinine values.

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