Abstract
Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.
Original language | English (US) |
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Title of host publication | Methods in Molecular Biology |
Publisher | Humana Press Inc. |
Pages | 291-299 |
Number of pages | 9 |
DOIs | |
State | Published - 2021 |
Publication series
Name | Methods in Molecular Biology |
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Volume | 2221 |
ISSN (Print) | 1064-3745 |
ISSN (Electronic) | 1940-6029 |
Bibliographical note
Publisher Copyright:© Springer Science+Business Media, LLC, part of Springer Nature 2021.
Keywords
- Evoked pain
- Functional assays
- Incapacitance
- Mechanical allodynia
- Open-field activity assays
- Static weight bearing
- von Frey
- Extremities/physiology
- Musculoskeletal Pain
- Pain Measurement/methods
- Hyperalgesia
- Behavior, Animal
- Animals
- Pain Threshold
- Weight-Bearing
- Mice
- Disease Models, Animal
PubMed: MeSH publication types
- Research Support, Non-U.S. Gov't
- Journal Article
- Research Support, N.I.H., Extramural