Pain and activity measurements

David H.H. Molstad; Elizabeth W. Bradley

doi:10.1007/978-1-0716-0989-7_17

Pain and activity measurements

David H.H. Molstad, Elizabeth W. Bradley

Orthopaedic Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	291-299
Number of pages	9
Volume	2221
DOIs	https://doi.org/10.1007/978-1-0716-0989-7_17
State	Published - 2021

Publication series

Name	Methods in Molecular Biology
Volume	2221
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Bibliographical note

Funding Information:
This work was made possible by training and research grants from the National Institutes of Health (AR065397 and AR072634) and the University of Minnesota Stem Cell Institute and Board of Regents. These contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

Keywords

Evoked pain
Functional assays
Incapacitance
Mechanical allodynia
Open-field activity assays
Static weight bearing
von Frey

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

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10.1007/978-1-0716-0989-7_17

Cite this

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AU - Bradley, Elizabeth W.

N1 - Funding Information: This work was made possible by training and research grants from the National Institutes of Health (AR065397 and AR072634) and the University of Minnesota Stem Cell Institute and Board of Regents. These contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

PY - 2021

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AB - Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.

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KW - Functional assays

KW - Incapacitance

KW - Mechanical allodynia

KW - Open-field activity assays

KW - Static weight bearing

KW - von Frey

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VL - 2221

T3 - Methods in Molecular Biology

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BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Pain and activity measurements

Abstract

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Keywords

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