Pain and activity measurements

David H.H. Molstad; Elizabeth W. Bradley

doi:10.1007/978-1-0716-0989-7_17

Pain and activity measurements

David H.H. Molstad, Elizabeth W. Bradley

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	291-299
Number of pages	9
DOIs	https://doi.org/10.1007/978-1-0716-0989-7_17
State	Published - 2021

Publication series

Name	Methods in Molecular Biology
Volume	2221
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Bibliographical note

Funding Information:
This work was made possible by training and research grants from the National Institutes of Health (AR065397 and AR072634) and the University of Minnesota Stem Cell Institute and Board of Regents. These contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2021.

Keywords

Evoked pain
Functional assays
Incapacitance
Mechanical allodynia
Open-field activity assays
Static weight bearing
von Frey
Extremities/physiology
Musculoskeletal Pain
Pain Measurement/methods
Hyperalgesia
Behavior, Animal
Animals
Pain Threshold
Weight-Bearing
Mice
Disease Models, Animal

PubMed: MeSH publication types

Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural

Publisher link

10.1007/978-1-0716-0989-7_17

Find It

Find It at U of M Libraries

Cite this

@inbook{c571383d3d324c4f8f01c90cbbf46db7,

title = "Pain and activity measurements",

abstract = "Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.",

keywords = "Evoked pain, Functional assays, Incapacitance, Mechanical allodynia, Open-field activity assays, Static weight bearing, von Frey, Extremities/physiology, Musculoskeletal Pain, Pain Measurement/methods, Hyperalgesia, Behavior, Animal, Animals, Pain Threshold, Weight-Bearing, Mice, Disease Models, Animal",

author = "Molstad, {David H.H.} and Bradley, {Elizabeth W.}",

note = "Funding Information: This work was made possible by training and research grants from the National Institutes of Health (AR065397 and AR072634) and the University of Minnesota Stem Cell Institute and Board of Regents. These contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2021.",

year = "2021",

doi = "10.1007/978-1-0716-0989-7_17",

language = "English (US)",

series = "Methods in Molecular Biology",

publisher = "Humana Press Inc.",

pages = "291--299",

booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Pain and activity measurements

AU - Molstad, David H.H.

AU - Bradley, Elizabeth W.

N1 - Funding Information: This work was made possible by training and research grants from the National Institutes of Health (AR065397 and AR072634) and the University of Minnesota Stem Cell Institute and Board of Regents. These contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Publisher Copyright: © Springer Science+Business Media, LLC, part of Springer Nature 2021.

PY - 2021

Y1 - 2021

N2 - Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.

AB - Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.

KW - Evoked pain

KW - Functional assays

KW - Incapacitance

KW - Mechanical allodynia

KW - Open-field activity assays

KW - Static weight bearing

KW - von Frey

KW - Extremities/physiology

KW - Musculoskeletal Pain

KW - Pain Measurement/methods

KW - Hyperalgesia

KW - Behavior, Animal

KW - Animals

KW - Pain Threshold

KW - Weight-Bearing

KW - Mice

KW - Disease Models, Animal

UR - http://www.scopus.com/inward/record.url?scp=85091774287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85091774287&partnerID=8YFLogxK

U2 - 10.1007/978-1-0716-0989-7_17

DO - 10.1007/978-1-0716-0989-7_17

M3 - Chapter

C2 - 32979210

AN - SCOPUS:85091774287

T3 - Methods in Molecular Biology

SP - 291

EP - 299

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Pain and activity measurements

Abstract

Publication series

Bibliographical note

Keywords

PubMed: MeSH publication types

Publisher link

Find It

Other files and links

Fingerprint

Cite this