Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells

Jia Ouyang, Hui Xu, Ming Li, Xingliang Dai, Fengqing Fu, Xueguang Zhang, Qing Lan

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15 Scopus citations


Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We found that PF inhibited glioma cell proliferation, migration and invasion, and induced G2/M arrest and apoptosis. Skp2 expression was downregulated in glioma cells treated with PF. PF-induced antitumor effects in glioma cells were abolished by Skp2 over-expression but were enhanced by RNA interference of Skp2. Moreover, PF treatment inhibited U87 cell-derived tumor growth in a xenograft mouse model. These results demonstrate that PF exerts its antitumor effects in part by inhibiting Skp2 expression in glioma cells and could be a promising therapeutic agent for glioma therapy.

Original languageEnglish (US)
Pages (from-to)1052-1062
Number of pages11
JournalOncology Reports
Issue number3
StatePublished - Mar 2018
Externally publishedYes

Bibliographical note

Funding Information:
The present study study was financially supported by the following grants: the Program of Medical Innovation Team and Leading Talent of Jiangsu Province, China (no. LJ201150); the Science and Technology Plan Projects of Jiangsu Province, China (no. BL2012048) and the National Natural Sciences Foundation of China (no. 81572480).


  • Glioma
  • Paeoniflorin
  • Skp2


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