Paediatric genitourinary cancers and late effects of treatment

Karim T. Sadak, Michael L. Ritchey, Jeffrey S. Dome

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


The most common childhood genitourinary cancers are Wilms tumour, rhabdomyosarcoma and germ cell tumour (GCT). Long-term survival rates for patients with these tumours are generally excellent, ranging from 80% to 100%. However, the high cure rates have highlighted the need to minimize the long-term complications of treatments (referred to as 'late effects'), which can be caused by the three treatment modalities used to treat genitourinary tumours: surgery, chemotherapy and radiation therapy. Serious late effects, such as death, second cancers and tumour recurrence, are uncommon but do occur occasionally. Chronic health conditions - such as cardiac, pulmonary and fertility disorders - are more prevalent. Given the high prevalence of late effects, survivors of childhood genitourinary malignancies require regular surveillance and health promotion delivered by health-care providers with specialist knowledge of the long-term complications of treatment.

Original languageEnglish (US)
Pages (from-to)15-25
Number of pages11
JournalNature Reviews Urology
Issue number1
StatePublished - Jan 1 2013


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