Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment

David E. Williams, Doralyn S. Dalisay, Brian O. Patrick, Teatulohi Matainaho, Kerry Andrusiak, Raamesh Deshpande, Chad L. Myers, Jeff S. Piotrowski, Charles Boone, Minoru Yoshida, Raymond J. Andersen

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Abstract

Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

Original languageEnglish (US)
Pages (from-to)3936-3939
Number of pages4
JournalOrganic Letters
Volume13
Issue number15
DOIs
StatePublished - Aug 5 2011

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    Williams, D. E., Dalisay, D. S., Patrick, B. O., Matainaho, T., Andrusiak, K., Deshpande, R., Myers, C. L., Piotrowski, J. S., Boone, C., Yoshida, M., & Andersen, R. J. (2011). Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment. Organic Letters, 13(15), 3936-3939. https://doi.org/10.1021/ol2014494