Pacemakers in aggregation fields of Dictyostelium discoideum: does a single cell suffice?

G. DeYoung, P. B. Monk, H. G. Othmer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

In this paper we address the following question: can a single cell of the cellular slime mold Dictyostelium discoideum serve as a pacemaker for the aggregation phase? Whether or not this is possible is determined by the relative importance of cyclic AMP production due to self-stimulation as compared to diffusion of cyclic AMP away from the cell and extracellular degradation. We determine the conditions under which a single cell on an infinite place can emit periodic signals of cyclic AMP using a model developed previously for signal relay and adaptation in Dictyostelium. Elsewhere it has been shown that this model provides an accurate representation of the stimulus-response behavior of Dictyostelium for a variety of experimental conditions.

Original languageEnglish (US)
Pages (from-to)487-517
Number of pages31
JournalJournal of Mathematical Biology
Volume26
Issue number5
DOIs
StatePublished - Oct 1988

Keywords

  • Diffusion
  • Self-stimulation
  • Single cell pacemaker

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