p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer

Lakshana Sruthi Sadu Murari; Sam Kunkel; Anala Shetty; Addison Bents; Aayush Bhandary; Juan Carlos Rivera-Mulia

doi:10.3390/cells14010043

p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer

Lakshana Sruthi Sadu Murari
, Sam Kunkel
, Anala Shetty
, Addison Bents
, Aayush Bhandary
, Juan Carlos Rivera-Mulia

Biochemistry, Molecular Biology, and Biophysics (TMED)

Research output: Contribution to journal › Review article › peer-review

Abstract

The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature aging, and cancer. The effects of p63 are carried out by two main isoforms that regulate cell proliferation and senescence. p63 also controls the epigenome by regulating interactions with histone modulators, such as the histone acetyltransferase p300, deacetylase HDAC1/2, and DNA methyltransferases. miRNA-p63 interactions are also critical regulators in the context of cancer metastasis. This review aims to elaborate on the diverse roles of p63, focusing on disease, development, and the mechanisms controlling genome organization and function.

Original language	English (US)
Article number	43
Journal	Cells
Volume	14
Issue number	1
DOIs	https://doi.org/10.3390/cells14010043
State	Published - Jan 2025

Bibliographical note

Publisher Copyright:
© 2025 by the authors.

Keywords

TP63
aging
disease
genome organization
senescence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells14010043

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abstract = "The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature aging, and cancer. The effects of p63 are carried out by two main isoforms that regulate cell proliferation and senescence. p63 also controls the epigenome by regulating interactions with histone modulators, such as the histone acetyltransferase p300, deacetylase HDAC1/2, and DNA methyltransferases. miRNA-p63 interactions are also critical regulators in the context of cancer metastasis. This review aims to elaborate on the diverse roles of p63, focusing on disease, development, and the mechanisms controlling genome organization and function.",

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AU - Sadu Murari, Lakshana Sruthi

AU - Kunkel, Sam

AU - Shetty, Anala

AU - Bents, Addison

AU - Bhandary, Aayush

AU - Rivera-Mulia, Juan Carlos

PY - 2025/1

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N2 - The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature aging, and cancer. The effects of p63 are carried out by two main isoforms that regulate cell proliferation and senescence. p63 also controls the epigenome by regulating interactions with histone modulators, such as the histone acetyltransferase p300, deacetylase HDAC1/2, and DNA methyltransferases. miRNA-p63 interactions are also critical regulators in the context of cancer metastasis. This review aims to elaborate on the diverse roles of p63, focusing on disease, development, and the mechanisms controlling genome organization and function.

AB - The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature aging, and cancer. The effects of p63 are carried out by two main isoforms that regulate cell proliferation and senescence. p63 also controls the epigenome by regulating interactions with histone modulators, such as the histone acetyltransferase p300, deacetylase HDAC1/2, and DNA methyltransferases. miRNA-p63 interactions are also critical regulators in the context of cancer metastasis. This review aims to elaborate on the diverse roles of p63, focusing on disease, development, and the mechanisms controlling genome organization and function.

KW - TP63

KW - aging

KW - disease

KW - genome organization

KW - senescence

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UR - https://www.scopus.com/pages/publications/85214454932#tab=citedBy

U2 - 10.3390/cells14010043

DO - 10.3390/cells14010043

M3 - Review article

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AN - SCOPUS:85214454932

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p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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