p53 translational control: A new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics

Marie Jo Halaby, DaQing Yang

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

While posttranslational regulation of p53 levels by its interaction with the ubiquitin ligase MDM2 is widely accepted, it has recently become clear that regulation of p53 translation also contributes to p53 induction following DNA damage. However, the mechanisms underlying the translational control of p53 are still poorly understood. In this review, we will focus on the translational regulation of p53 through the 5′- and 3′-untranslated regions of its mRNA. We will also discuss in detail the recent discovery of the p53 internal ribosome entry site (IRES), its role in p53 translation in response to DNA damage, and how it might lead to a better understanding of the process of oncogenesis and provide new avenues for cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalGene
Volume395
Issue number1-2
DOIs
StatePublished - Jun 15 2007
Externally publishedYes

Keywords

  • 3′-untranslated region
  • 5′-untranslated region
  • DNA damage
  • Internal ribosome entry site

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