Objective: P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. Methods: Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events. Results: Mean levels of P-selectin differed by ethnicity and were higher in men (P<0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027). Conclusion: We observed ethnic heterogeneity in the association of P-selectin and risk of CHD.
|Original language||English (US)|
|Number of pages||7|
|State||Published - May 1 2015|
Bibliographical noteFunding Information:
This study was funded by MESA. MESA is conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with MESA investigators (Grants and contracts N01 HC-95159 , N01-HC-95160 , N01-HC-95161 , N01-HC-95162 , N01-HC-95163 , N01-HC-95164 , N01-HC-95165 , N01-HC-95166 , N01-HC-95167 , N01-HC-95168 , N01-HC-95169 and RR-024156 ). Funding to support adhesion protein measurements was provided by NHLBI ( R01 HL98077 , for abdominal aortic CT by grant R01 HL088451, and for IMT measurements by grants R01 HL069003 and R01 HL081352).
© 2015 Elsevier Ireland Ltd.
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- Cardiovascular risk factors
- Coronary artery calcium