P. gingivalis interactions with epithelial cells

Denis F. Kinane, Johnah Cortez Galicia, Sven Ulrik Gorr, Panagiota Giorgios Stathopoulou, Manjunatha Benakanakere

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


Dental plaque, a microbial biofilm that accumulates on teeth and initiates periodontal disease, is composed of hundreds of different bacterial species within an organized structure. The biofilm bacteria and their byproducts irritate the gingival epithelium and induce an "inflammatory response". The perturbation of epithelial cells by bacteria is the first stage in the initiation of inflammatory and immune processes which eventually cause destruction of the tissues surrounding and supporting the teeth, and ultimately result in tooth loss. This review addresses the early bacterial-epithelial cell interactions and the subsequent responses of the epithelial cell. It includes discussion of how epithelial Toll-like receptors (TLRs) respond to different bacterial challenges, the variable antimicrobial peptides released and the host signaling responses which trigger release of these molecules and the overall fate of these cells in terms of survival, apoptosis, or cell lysis.

Original languageEnglish (US)
Pages (from-to)966-984
Number of pages19
JournalFrontiers in Bioscience
Issue number3
StatePublished - 2008


  • Apoptosis
  • Epithelial cell
  • Innate
  • P. gingivalis
  • Review
  • Toll-like receptors


Dive into the research topics of 'P. gingivalis interactions with epithelial cells'. Together they form a unique fingerprint.

Cite this