p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

José Correa-Basurto, Iván Vázquez Alcántara, L. Michel Espinoza-Fonseca, José G. Trujillo-Ferrara

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32 Scopus citations


Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.

Original languageEnglish (US)
Pages (from-to)732-735
Number of pages4
JournalEuropean Journal of Medicinal Chemistry
Issue number7
StatePublished - Jul 2005

Bibliographical note

Funding Information:
The authors thank CONACYT and CGPI for financial support. L.M.E.F. thanks the Ministry of Education of the Slovak Republic for the fellowship granted during the academic year 2003–2004.


  • Acetylcholine
  • Acetylcholinesterase
  • Amides
  • Enzymatic inhibitors
  • Imides
  • Molecular docking


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