p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

José Correa-Basurto; Iván Vázquez Alcántara; L. Michel Espinoza-Fonseca; José G. Trujillo-Ferrara

doi:10.1016/j.ejmech.2005.03.011

p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

José Correa-Basurto, Iván Vázquez Alcántara, L. Michel Espinoza-Fonseca, José G. Trujillo-Ferrara

Biochemistry, Molecular Biology, and Biophysics (TMED)

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.

Original language	English (US)
Pages (from-to)	732-735
Number of pages	4
Journal	European Journal of Medicinal Chemistry
Volume	40
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2005.03.011
State	Published - Jul 2005

Bibliographical note

Funding Information:
The authors thank CONACYT and CGPI for financial support. L.M.E.F. thanks the Ministry of Education of the Slovak Republic for the fellowship granted during the academic year 2003–2004.

Keywords

Acetylcholine
Acetylcholinesterase
Amides
Enzymatic inhibitors
Imides
Molecular docking

Publisher link

10.1016/j.ejmech.2005.03.011

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title = "p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors",

abstract = "Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.",

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note = "Funding Information: The authors thank CONACYT and CGPI for financial support. L.M.E.F. thanks the Ministry of Education of the Slovak Republic for the fellowship granted during the academic year 2003–2004.",

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doi = "10.1016/j.ejmech.2005.03.011",

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AU - Correa-Basurto, José

AU - Alcántara, Iván Vázquez

AU - Espinoza-Fonseca, L. Michel

AU - Trujillo-Ferrara, José G.

N1 - Funding Information: The authors thank CONACYT and CGPI for financial support. L.M.E.F. thanks the Ministry of Education of the Slovak Republic for the fellowship granted during the academic year 2003–2004.

PY - 2005/7

Y1 - 2005/7

N2 - Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.

AB - Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.

KW - Acetylcholine

KW - Acetylcholinesterase

KW - Amides

KW - Enzymatic inhibitors

KW - Imides

KW - Molecular docking

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M3 - Article

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SN - 0223-5234

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IS - 7

ER -

p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

Abstract

Bibliographical note

Keywords

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