Initial studies showed that the anorexigenic peptide oxytocin (OT) regulates gastric motility, responds to stomach distention and to elevated osmolality, and blocks consumption of toxic foods. Most recently, it has been proposed to act as a mediator of general and carbohydrate-specific satiety and regulator of body weight. In the current review, we discuss the function of OT as a homeostatic inhibitor of consumption, capable of mitigating multiple aspects of ingestive behavior and energy metabolism.
Bibliographical noteFunding Information:
The studies were supported by the Swedish Research Counc il (VR), the Swedish Brain Research Foundation and the Novo Nordisk Foundation .
- Paraventricular nucleus of the hypothalamus
- Taste aversion