Oxytocin as feeding inhibitor: Maintaining homeostasis in consummatory behavior

Pawel K. Olszewski, Anica Klockars, Helgi B. Schiöth, Allen S Levine

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Initial studies showed that the anorexigenic peptide oxytocin (OT) regulates gastric motility, responds to stomach distention and to elevated osmolality, and blocks consumption of toxic foods. Most recently, it has been proposed to act as a mediator of general and carbohydrate-specific satiety and regulator of body weight. In the current review, we discuss the function of OT as a homeostatic inhibitor of consumption, capable of mitigating multiple aspects of ingestive behavior and energy metabolism.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume97
Issue number1
DOIs
StatePublished - Nov 2010

Bibliographical note

Funding Information:
The studies were supported by the Swedish Research Counc il (VR), the Swedish Brain Research Foundation and the Novo Nordisk Foundation .

Keywords

  • Anorexia
  • Obesity
  • Paraventricular nucleus of the hypothalamus
  • Pituitary
  • Sugar
  • Taste aversion

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