Oxygenation of the pancreas

Amy C. Kelly, Thomas M. Suszynski, Klearchos K Papas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human pancreas and islet transplantation remains an attractive treatment option for some patients with severe type 1 diabetes (T1D). Pancreas preservation remains a critically important part of the success and cost-effectiveness of pancreas and especially islet transplantation. During preservation, the pancreas is susceptible to ischemia that has been shown to reduce the quality and function of the pancreas and likely predisposes islets to further damage during the islet isolation process when islet transplantation is pursued. It is widely accepted that improving the oxygenation during preservation improves pancreas and islet quality, which may be able to expand the donor pool, extend the preservation time, improve islet yield and quality, and ultimately reduce the number of donors needed per patient. This chapter discusses the challenges in pancreas preservation especially as they relate to the unique susceptibility of islets to ischemia and then concludes with a discussion on current clinical and research methodologies used for pancreas preservation in pancreas and islet transplantation with a focus on how they address the issue of oxygenation during preservation. Through discussion of these methodologies, we underscore the critical need for improved oxygen delivery to human pancreata during preservation.

Original languageEnglish (US)
Title of host publicationPancreas and Beta Cell Replacement
PublisherElsevier
Pages113-124
Number of pages12
ISBN (Electronic)9780128240113
ISBN (Print)9780128240120
DOIs
StatePublished - Jan 1 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Keywords

  • Ischemia
  • Islets
  • Oxygenation
  • Pancreas preservation

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