Oxygen-generating polycaprolactone/calcium peroxide microparticles to support cell survival in hypoxic environment

Mengen Zhang, Tawan Kiratiwongwan, Wei Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Oxygen is required to support viability and functionality of cells in tissue engineering. However, limited oxygen supply through diffusion is a major challenge for engineering large tissue constructs, particularly those containing metabolically active cells. Embedding oxygen releasing materials in engineered scaffolds to maintain a high level of oxygen in the inner parts of large tissue constructs is one approach to addressing this challenge. Here we develop oxygen-generating microparticles by encapsulating calcium peroxide (CaO2) in polycaprolactone (PCL) through homogenization and electrospraying to sustain prolonged oxygen release. The degradation of biodegradable PCL allows the controlled release of encapsulated CaO2, which then reacts with water to generate O2 to supply a tissue construct.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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Zhang, M., Kiratiwongwan, T., & Shen, W. (2019). Oxygen-generating polycaprolactone/calcium peroxide microparticles to support cell survival in hypoxic environment. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.