Oxoiron(IV) complexes of the tris(2-pyridylmethyl)amine ligand family: Effect of pyridine α-substituents

Tapan K. Paine, Miquel Costas, József Kaizer, Lawrence Que

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Abstract

The oxoiron(IV) complexes of two 6-substituted tris(2-pyridylmethyl)amine ligand derivatives have been generated and characterized with respect to their spectroscopic and reactivity properties. The introduction of an α-substituent maintains the low-spin nature of the oxoiron(IV) unit but weakens the ligand field, as evidenced by red shifts in its characteristic near-IR chromophore. While its hydrogen-atom abstraction ability is only slightly affected, the oxo-transfer reactivity of the oxoiron(IV) center is significantly enhanced relative to that of the parent complex. These results demonstrate that the ligand environment plays a key role in modulating the reactivity of this important biological oxidant.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalJournal of Biological Inorganic Chemistry
Volume11
Issue number3
DOIs
StatePublished - Apr 2006

Bibliographical note

Funding Information:
Acknowledgement This work was supported by grant GM33162 from the National Institutes of Health to L.Q.

Keywords

  • Nonheme iron intermediates
  • Oxoiron(IV) complexes
  • Taurine/α-ketoglutarate dioxygenase
  • Tris(2-pyridylmethyl)amine

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