Abstract
The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension and insulin resistance. It is associated with a high cardiovascular risk that can only partially be explained by its components. There is evidence that low-grade inflammation and high oxidative stress add to this risk. Oxidized LDL, a marker of lipoprotein-associated oxidative stress, is an emerging cardiovascular risk factor. In this review, we demonstrate that the metabolic syndrome exacerbates oxidized LDL in a feedback loop. We introduce molecular mechanisms underlying this loop. Finally, we demonstrate that weight loss and statin treatment lower metabolic syndrome factors associated with a reduction of oxidized LDL. The current data warrant further investigation into the role of lifestyle and therapeutic interventions that inhibit tissue-associated oxidation of LDL in the prevention of the metabolic syndrome.
Original language | English (US) |
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Pages (from-to) | 637-649 |
Number of pages | 13 |
Journal | Future Lipidology |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - 2008 |
Keywords
- Atherosclerosis
- Inflammation
- Metabolic syndrome
- Obesity
- Oxidative stress
- Oxidized LDL