Oxidative stress and impaired insulin secretion in type 2 diabetes

R. Paul Robertson

doi:10.1016/j.coph.2006.09.002

Oxidative stress and impaired insulin secretion in type 2 diabetes

R. Paul Robertson

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

Molecular mechanisms involving oxidative stress have been increasingly implicated in the pathogenesis of type 2 diabetes. These implications have arisen from reports that glucolipotoxicity of the pancreatic islet and non-islet tissues can lead to deterioration of islet function and insulin sensitivity, as well as structural abnormalities in tissues adversely affected by diabetes. Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1.

Original language	English (US)
Pages (from-to)	615-619
Number of pages	5
Journal	Current Opinion in Pharmacology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.coph.2006.09.002
State	Published - Dec 2006
Externally published	Yes

Bibliographical note

Funding Information:
Supported in part by NIH grant NIDDK RO-1 38325.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.coph.2006.09.002

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title = "Oxidative stress and impaired insulin secretion in type 2 diabetes",

abstract = "Molecular mechanisms involving oxidative stress have been increasingly implicated in the pathogenesis of type 2 diabetes. These implications have arisen from reports that glucolipotoxicity of the pancreatic islet and non-islet tissues can lead to deterioration of islet function and insulin sensitivity, as well as structural abnormalities in tissues adversely affected by diabetes. Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1.",

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N1 - Funding Information: Supported in part by NIH grant NIDDK RO-1 38325.

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Y1 - 2006/12

N2 - Molecular mechanisms involving oxidative stress have been increasingly implicated in the pathogenesis of type 2 diabetes. These implications have arisen from reports that glucolipotoxicity of the pancreatic islet and non-islet tissues can lead to deterioration of islet function and insulin sensitivity, as well as structural abnormalities in tissues adversely affected by diabetes. Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1.

AB - Molecular mechanisms involving oxidative stress have been increasingly implicated in the pathogenesis of type 2 diabetes. These implications have arisen from reports that glucolipotoxicity of the pancreatic islet and non-islet tissues can lead to deterioration of islet function and insulin sensitivity, as well as structural abnormalities in tissues adversely affected by diabetes. Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1.

UR - https://www.scopus.com/pages/publications/33750502270

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U2 - 10.1016/j.coph.2006.09.002

DO - 10.1016/j.coph.2006.09.002

M3 - Review article

C2 - 17045527

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ER -

Oxidative stress and impaired insulin secretion in type 2 diabetes

Abstract

Bibliographical note

UN SDGs

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